【关键词】ModifiedSerotonin5-HT2Breceptorsareoftencoexpressedwith5-HT1Breceptors,andcross-talkbetweenthetworeceptorshasbeenreportedinvariouscelltypes.However,manymechanisticdetailsunderlying5-HT1Band5-HT2Breceptorcross-talkhavenotbeenelucidated.Wehypothesizedthat5-HT2Band5-HT1Breceptorseachaffe...
参考资料医源资料库；在线期刊；分子药理学杂志；2007年第69卷第6期...acterizationWithinthefamilyofserotoninreceptors,the5-hydroxytryptamine-3(5-HT3)receptoristheonlyligand-gatedionchannel.Itiscomposedoffivesubunits,ofwhichthe5-HT3Aand5-HT3Bsubunitsarebestcharacterized.Severalstudies,however,havereportedonthefunctionaldiversityofnative5-HT3receptors,whichcannotsolelyb...
参考资料医源资料库；在线期刊；分子药理学杂志；2007年第69卷第7期...GICs.Here,wereportthatAEAinhibitedthefunctionofserotoningatedionchannels(5-HT3A)expressedinXenopuslaevisoocytesandhumanembryonickidney293cellsinamannerthatwasdependentonthesteady-statereceptordensityatthecellsurface.ThemagnitudeofAEAinhibitionwasinverselycorrelatedwiththeexpressionlevelsofreceptorpr...
参考资料医源资料库；在线期刊；分子药理学杂志；2008年第70卷第2期...键词】RisperidoneRisperidonedisplaysanovelmechanismofantagonismoftheh5-HT7receptor.Pretreatmentofthecellswith5or20nMrisperidone,followedbyremovalofthedrugfromthemedia,rendersthe5-HT7receptorsunresponsiveto10µM5-HTforatleast24h.Thus,risperidoneseemstobeproducingarapid,long-lastinginactivatio...
参考资料医源资料库；在线期刊；分子药理学杂志；2006年第68卷第10期...ftheECbyactivatingtheTWIK-1typeofthetwo-poredomainK+channels.Theeffectsof5-HTweremediatedvia5-HT1AreceptorsandrequiredthefunctionofGi3subunitandproteinkinaseA.Serotonin-mediatedinhibitionofECactivityresultedinaninhibitionofhippocampalfunction.Ourstudyprovidesacellularmechanismthatmightatleastpartial...
参考资料医源资料库；在线期刊；分子药理学杂志；2007年第69卷第7期...leftventriclehasbecomesensitivetoserotoninbecauseofappearanceofGs-coupled5-HT4receptors.WhetherthisalsooccursinacuteCHFisunknown.Serotoninresponsivenessmaydevelopgraduallyorrepresentanearlyresponsetotheinsult.Furthermore,serotoninreceptorexpressioncouldvarywithprogressionofthedisease.PostinfarctionC...
参考资料医源资料库；在线期刊；循环研究杂志；2005年第95卷第8期...essedthedose–responsecurveforthe2Cagonist.Rapiddesensitizationoccurredwiththe2Cagonistonly(p0.05).The7antagonist,SB-269,970,hadnoeffectoneitherintrinsicactivityoragonistresponses.Weconcludethatserotonin2Aisthepredominantexcitatoryserotoninreceptorsubtypeathypoglossalmotorneurons.Theserotonin2Cexci...
参考资料医源资料库；在线期刊；美国呼吸和危急护理医学；2003年第167卷第4期...e-threateningcardiovascularsideeffects.SNFreducesappetitethroughserotonin5-HT2Creceptoractivation;itcausescardiopulmonarysideeffectsthrough5-HT2Breceptoractivation.Thus,weattemptedtoidentifymoleculardeterminantsofSNFbindingto5-HT2BreceptorsdistinctfromthoseunderlyingSNF-5-HT2C/2Areceptorinteractions...
参考资料医源资料库；在线期刊；分子药理学杂志；2006年第68卷第1期...词】5-Hydroxytryptamine-1ANumerousdatashowedthat5-hydroxytryptamine-1A(5-HT1A)receptorscoupletoGo/iproteinsforsignaltransduction.However,thesubunitisoformsreallyinvolvedin5-HT1Areceptorcouplinginbrainremaintobeidentified.Moreover,regionaldifferencesinthefunctionalcharacteristicsofbrain5-HT1Arecept...
参考资料医源资料库；在线期刊；分子药理学杂志；2006年第68卷第9期【关键词】InverseDespitetheimportanceof5-hydroxytryptamine(5-HT)2C(serotonin)receptorsinthecontrolofdepressivestates,actionsofantidepressantsatthesereceptorsremainpoorlycharacterized.Thisissuewasaddressedbothinhumanembryonickidney(HEK)-293cellscoexpressinguneditedhuman5-HT2CINIreceptorsandGqpro...
参考资料医源资料库；在线期刊；分子药理学杂志；2008年第70卷第3期