...wetestedwhetherouabainmodulatesendothelialcytoplasmiccalciumconcentration([Ca2+]CYT)inratdescendingvasarecta(DVR).Overabroadrangebetween10-10and10-4M,ouabainelicitedbiphasicpeakandplateau[Ca2+]CYTelevations.Blockadeofvoltage-gatedCa2+entrywithnifedipinedidnotaffecttheresponsetoouabainmitigatingagain...
参考资料医源资料库；在线期刊；美国生理学杂志；2006年第289卷第10期...要】Vasoconstrictionandincreaseintheintracellularcalciumconcentration([Ca2+]i)ofvascularsmoothmusclecellsmaycauseanincreaseofendothelialcell[Ca2+]i,which,inturn,augmentsnitricoxide(NO)productionandinhibitssmoothmusclecellcontraction.Thishypothesiswastestedinmicroperfusedrabbitrenalafferentarteriol...
参考资料医源资料库；在线期刊；美国生理学杂志；2007年第290卷第4期...tionofANGIIdirectlyinsinglePTCsincreasesintracellularcalciumconcentration([Ca2+]i)and,ifso,elucidatedthecellularmechanismsinvolved.Changesin[Ca2+]iresponseswerestudiedbyfluorescenceimagingusingtheCa2+indicatorfluo3.ANGII(1nM)wasmicroinjecteddirectlyinthecells,whereascell-surfaceangiotensintype1(AT1)...
参考资料医源资料库；在线期刊；美国生理学杂志；2006年第289卷第6期...stoelucidatethemechanismofthissynergisticactionwithafocusontheintracellularCa2+concentration([Ca2+]i)andthevariousplateletreceptorsforthrombin.MethodsandResults—Wedemonstratethatprocoagulantactivityisrelatedtoasustainedincreased[Ca2+]i,whichinturndependsonextracellularCa2+influx.IncreasedPtdSerexp...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第7期...larsmoothmusclecells(VSMCs)haveanabnormalphenotypeanddefectiveintracellularCa2+([Ca2+]i)regulation.WeexaminedcAMPcontentinvascularsmoothmusclesfromPkd2+/eCmicebecausecAMPiselevatedincysticrenalepithelialcells.WefoundcAMPconcentrationwassignificantlyincreasedinPkd2+/eCvesselscomparedwithwild-typevess...
参考资料医源资料库；在线期刊；循环研究杂志；2005年第95卷第4期...fromratkidneyandloadedwithfura2.Endothelin-1(ET-1)rapidlyincreasedcytosolicCa2+concentration([Ca2+]i)by303nM.Thesuperoxidedismutasemimetictempol,theNAD(P)Hoxidaseinhibitorapocynin,andnicotinamide,aninhibitorofADPRcyclase,diminishedtheresponseby60%.TheETBRagonistsarafotoxin6c(S6c)increasedpeak[Ca2+]i...
参考资料医源资料库；在线期刊；美国生理学杂志；2007年第290卷第1期...(ADPR)cyclase,andamplificationoftheinitialIP3R-stimulatedreleaseofcytosolicCa2+([Ca2+]i)fromthesarcoplasmicreticulum(SR)(FellnerSK,ArendshorstWJ.AmJPhysiolRenalPhysiol288:F785-F791,2004).Theresponseoftheryanodinereceptor(RyR)tolocalincreasesin[Ca2+]iisdefinedascalcium-inducedcalciumrelease(CICR).Toi...
参考资料医源资料库；在线期刊；美国生理学杂志；2007年第290卷第5期...nofextracellularAAinthemodulationofthepurinoceptorP2X7-mediatedelevationof[Ca2+]iinculturedneocorticaltype-1astrocytesandP2X7-,P2X2-transfectedhumanembryonickidney(HEK)293cells.Wereportthatinculturedastrocytes,AA-induced[Ca2+]ielevationiscoupledtodepletionofintracellularCa2+storesandtoasustainednonc...
参考资料医源资料库；在线期刊；分子药理学杂志；2006年第68卷第6期...nnorepinephrine(NE)-inducedchangesinintracellularfreecalciumconcentration([Ca2+]i)inratafferentarterioles.[Ca2+]iwasmeasuredinmicrodissectedarteriolesusingratiometricphotometryoffura2fluorescence.Thecontrol[Ca2+]iresponsetoNE(1µM)consistedofarapidinitialpeakfollowedbyaplateauphasesustainedabov...
参考资料医源资料库；在线期刊；美国生理学杂志；2004年第287卷第5期...体重要的元素成分之一，在体内以结合状态和离子状态(Ca2＋)存在。但只有Ca2＋才具有生理活性。体内Ca2＋分为细胞内Ca2＋和细胞外Ca2＋两种，其中，胞质钙作为第二信使对细胞各种生理活动具有广泛调控作用。1．2第二信使作...
参考资料医源资料库；在线期刊；中华医学研究杂志；2009年第9卷第3期