找到22371条结果，用时1.059s
  • InhibitionofInterleukin1Receptor/Toll-likeReceptorSignalingthroughtheAlternativelySpliced,ShortFormofMyD88IsDuetoItsFailuretoRecruitIRAK

    ...inflammatoryinterleukin1receptor(IL-1R)familyaredependentonthepresenceofMyD88forefficientsignaltransduction.ThebipartitenatureofMyD88(N-terminaldeathdomain[DD]andCOOH-terminalToll/IL-1receptor[TIR]domain)allowsittolinktheTIRdomainofIL-1R/TLRwiththeDDoftheSer/ThrkinasetermedIL-1R–associatedkinase(I...

    参考资料医源资料库；在线期刊；美国病理学杂志；2003年第162卷第2期
  • InhibitionofInterleukin1Receptor/Toll-likeReceptorSignalingthroughtheAlternativelySpliced,ShortFormofMyD88IsDuetoItsFailuretoRecruitIRAK

    ...inflammatoryinterleukin1receptor(IL-1R)familyaredependentonthepresenceofMyD88forefficientsignaltransduction.ThebipartitenatureofMyD88(N-terminaldeathdomain[DD]andCOOH-terminalToll/IL-1receptor[TIR]domain)allowsittolinktheTIRdomainofIL-1R/TLRwiththeDDoftheSer/ThrkinasetermedIL-1R–associatedkinase(I...

    参考资料医源资料库；在线期刊；实验医学杂志；2003年第197卷第2期
  • MyD88-dependentinductionofallergicTh2responsestointranasalantigen

    ...atology,YaleUniversitySchoolofMedicine,NewHaven,Connecticut,USA.AbstractMyD88isacommonToll-likereceptor(TLR)adaptormoleculefoundtobeessentialforinductionofadaptiveTh1immunity.Conversely,innatecontrolofadaptiveTh2immunityhasbeenshowntooccurinaMyD88-independentmanner.Inthisstudy,weshowthatMyD88isaness...

    参考资料医源资料库；在线期刊；临床研究杂志；2005年第115卷第2期
  • WoundHealingIsImpairedinMyD-DeficientMice

    ...(VEGF).WeshowinthisstudythatthisswitchcriticallyrequiressignalingthroughMyD88,IRAK4,andTRAF6.MacrophagesfrommicelackingMyD88(MyD88C/C)orIRAK4(IRAK4C/C)lackedresponsivenesstoTLRagonistsanddidnotrespondtoA2ARagonistsbyexpressingVEGF.SuppressionofTRAF6expressionwithsiRNAinRAW264.7macrophagesalsoblocked...

    参考资料医源资料库；在线期刊；美国病理学杂志；2007年第169卷第12期
  • InnateimmunitymediatedbyTLR9modulatespathogenicityinananimalmodelofmultiplesclerosis

    ...unity,westudiedtheroleofdifferentTLRsaswellastheircommonsignalingadaptorMyD88inthedevelopmentofEAE.WefoundthatMyD88–/–micewerecompletelyEAEresistant.Surprisingly,thisprotectionispartlyduetoengagementoftheCpGreceptorTLR9.RestrictingtheMyD88orTLR9mutationtohostradio-resistantcells,includingthecell...

    参考资料医源资料库；在线期刊；临床研究杂志；2006年第116卷第2期
  • MyD88-dependentIL-1receptorsignalingisessentialforgoutyinflammationstimulatedbymonosodiumuratecrystals

    ...R(TIR)signaltransductionadaptormyeloiddifferentiationprimaryresponseprotein88(MyD88)isrequiredforacutegoutyinflammation.Incontrast,otherTIRadaptormolecules,TIRAP/Mal,TRIF,andTRAM,arenotrequiredforthisprocess.TheMyD88-dependentTLR1,-2,-4,-6,-7,-9,and-11andIL-18receptor(IL-18R)arenotessentialforMSU-in...

    参考资料医源资料库；在线期刊；临床研究杂志；2006年第116卷第8期
  • PROGEN公司第二期肝癌试验结果即将发表

    ...号：PGL，NASDAQ代号：PGLA）2007年4月16日宣布其抗癌药物PI-88适用于手术切除后肝癌患者第二期临床试验总结报告，试验48周的数据显示，PI-88可以有效降低25%的肝癌复发率，且可延长78%肝癌复发时间（27周延长到48周）。PI-88是Progen...

    参考资料行业资讯；临床快报；肿瘤相关
  • 88移植修复下颌后磨牙的临床观察

    【摘要】目的用阻生88移植修复下颌后磨牙的临床疗效观察。方法选择符合条件26例，28颗牙，根据X线片88根形成情况分成A、B两组，根完全形成者为A组，尚未完全形成者为B组。A组进行根管治疗后移植，B组不处理根管移植。结果...

    参考资料医源资料库；在线期刊；中华医学实践杂志；2005年第4卷第10期
  • AcuteBrainInjuryTriggersMyD-DependentTLR/-IndependentInflammatoryResponses

    ...swellasinneutrophilaccumulationinmicelackingthecommonTLRsignalingadaptorMyD88comparedwithwild-typemice.Notably,attenuationoftheimmuneresponsewasparalleledbyareductioninlesionsize.Neutrophildepletionofwild-typemiceandtransplantationofMyD88-deficientbonemarrowintolethallyirradiatedwild-typerecipientsh...

    参考资料医源资料库；在线期刊；美国病理学杂志；2007年第169卷第7期
  • TLR9/MyD88signalingisrequiredforclassswitchingtopathogenicIgG2aand2bautoantibodiesinSLE

    ...genicsubclassesrequirestheinnateimmunereceptorToll-likereceptor(TLR)9andMyD88signaling.Intheirabsence,switchingofautoreactiveBcellstotheIgG2aand2bsubclassesisblocked,resultinginreducedpathologyandmortality.Incontrast,switchingofanti-selfBcellstoIgG1isnotperturbedandgenerationofnonautoreactiveIgG2aan...

    参考资料医源资料库；在线期刊；实验医学杂志；2006年第203卷第3期

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