找到55189条结果，用时0.788s
  • p38MAPkinaseinhibitionamelioratescisplatinnephrotoxicityinmice

    ...cisplatinmediatestheproductionofTNF-andinjuryisnotknown.Cisplatinactivatesp38MAPKandinducesapoptosisincancercells.p38MAPKactivationleadstoincreasedproductionofTNF-inischemicinjuryandinmacrophages.However,littleisknownconcerningtheroleofp38MAPKincisplatin-inducedrenalinjury.Therefore,weexaminedtheeff...

    参考资料医源资料库；在线期刊；美国生理学杂志；2005年第288卷第7期
  • CD38isrequiredforprimingbyTNF-:amechanismforextracellularcoordinationofcellfate

    ...tokineTNF-iscapableofaffectingthefateofmacrophagesbyupregulatingtheNADaseCD38.CD38upregulationprimesmacrophages,suchthatsignalsinducedbyinflammatorystimuliareaugmented,whilethoseleadingtoosteoclastformationareinhibited.WeshowthatTNF--inducedCD38expressionnegativelyaffectstheexpressionofosteoclastmar...

    参考资料医源资料库；在线期刊；美国生理学杂志；2007年第290卷第4期
  • JX401,Ap38InhibitorContaininga4-BenzylpiperidineMotif,IdentifiedviaaNovelScreeningSysteminYeast

    ...wedescribetheidentificationofinhibitorsofthemitogen-activatedproteinkinasep38viaahighthroughputscreenusingyeastcells.p38ishyperactiveininflammatorydiseases,andvariousindicationssuggestthatitsinhibitionwouldreverseinflammation.However,therearecurrentlynop38inhibitorsinclinicaluse.Becausethehumanp38im...

    参考资料医源资料库；在线期刊；分子药理学杂志；2006年第68卷第10期
  • AMP-ActivatedProteinKinaseActivatesp38Mitogen-ActivatedProteinKinasebyIncreasingRecruitmentofp38MAPKtoTAB1intheIschemicHeart

    ...tress-signalingpathways.ThisstudyexaminedtheroleofAMPKintheactivationofthep38mitogen-activatedproteinkinase(MAPK).Inisolatedheartmuscles,theAMPKactivator5-aminoimidazole-4-carboxy-amide-1--D-ribofuranoside(AICAR)increasedp38MAPKactivation.InAMPK-deficientmousehearts,expressingakinase-dead(KD)2cataly...

    参考资料医源资料库；在线期刊；循环研究杂志；2005年第95卷第10期
  • Inhaledp38Mitogen-activatedProteinKinaseAntisenseOligonucleotideAttenuatesAsthmainMice

    ...fAntisenseDrugDiscovery,ISISPharmaceuticals,Carlsbad,CaliforniaABSTRACTThep38mitogen-activatedproteinkinase(MAPK)playsacriticalroleintheactivationofinflammatorycells.Therefore,weinvestigatedtheantiinflammatoryeffectsofarespirablep38MAPKantisenseoligonucleotide(p38-ASO)inamouseasthmamodel.Apotentands...

    参考资料医源资料库；在线期刊；美国呼吸和危急护理医学；2005年第171卷第3期
  • 上海生科院发现肝脏p38a对糖异生的调节机制

    生理和病理条件下肝脏p38a对糖异生的调节1月13日，《肝脏病学杂志》（JournalofHepatology）在线发表了中国科学院上海生命科学研究院营养科学研究所应浩组的最新研究成果：Hepaticp38aregulatesgluconeogenesisthroughsuppressingAMPK。该研究发...

    参考资料医药经济；生物技术；技术要闻
  • ERKandp38mediatehigh-glucose-inducedhypertrophyandTGF-expressioninrenaltubularcells

    【摘要】WeinvestigatedtheexpressionofERK,p38mitogen-activatedproteinkinase(p38),andJNKinrenaltubulesofdiabeticratsfollowing3wkafterstreptozotocininjection(DM).AlthoughtheexpressionofERKwasnotdifferentbetweencontrolsandDM,phosphorylatedERKwasexpressedmoreintenselyinDM.p38Andphosphorylatedp38wered...

    参考资料医源资料库；在线期刊；美国生理学杂志；2004年第287卷第1期
  • MechanicalStretchInducesPhosphorylationofp38-MAPKandApoptosisinHumanSaphenousVein

    ...terminewhetherpressuredistensionofhumansaphenousveininducestheactivationofp38-MAPKandtodetermineitsroleinapoptosis.MethodsandResults—Phosphorylatedp38wasdetectedatbasallevelsinhumansaphenousveinobtainedimmediatelyafterharvesting.Distendedsaphenousveinshowedsignificantlyhigherlevelsofphosphorylated...

    参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第3期
  • p38MAPK在局灶性脑缺血大鼠缺血中心区和半影区的表达

    ...究大鼠局灶性脑缺血不同缺血时间皮质半暗带和中心区p38丝裂原激活蛋白激酶(p38MAPK)磷酸化水平和蛋白水平的表达。方法用线栓法建立大鼠局灶性脑缺血模型,分别于术后1、3、6、12、24h剥取缺血半暗带及中心区皮质组织,应用Weste...

    参考资料医源资料库；在线期刊；滨州医学院学报；2009年第32卷第5期
  • IdentificationandFunctionalCharacterizationoftheHepaticStellateCellCDCellSurfaceMolecule

    ...initypurificationofthisproteinfollowedbysequencingrevealedthatproteintobeCD38.WesubsequentlydemonstratedthatCD38wasconstitutivelyexpressedbyHSCsandthatitsexpressionincreasedafterinvitroandinvivoactivation.mAb14.27inducedanincreaseincytosolicCa2+levelsinHSCs,showingthatitfunctionsasanagonisticantibod...

    参考资料医源资料库；在线期刊；美国病理学杂志；2007年第169卷第1期

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