找到9436条结果，用时0.272s
  • EffectofhydrogenperoxideonROMKchannelsinthecorticalcollectingduct

    【摘要】Weusedthepatch-clamptechniquetostudytheeffectofH2O2ontheapicalROMK-likesmall-conductanceK(SK)channelinthecorticalcollectingduct(CCD).TheadditionofH2O2decreasedtheactivityoftheSKchannelsandtheinhibitoryeffectofH2O2waslargerintheCCDfromratsonaK-deficientdietthanthatfromratsonanormal-Korahi...

    参考资料医源资料库；在线期刊；美国生理学杂志；2007年第290卷第4期
  • H2O2-inducedtransactivationofEGFreceptorrequiresSrcandmediatesERK1/2,butnotAkt,activationinrenalcells

    ...osureofprimaryculturesofrabbitrenalproximaltubularcellstohydrogenperoxide(H2O2)stimulatedSrc,EGFR,ERK1/2,andAktactivationinatime-dependentmannerasdeterminedbythephosphorylationofeachprotein.TheSrcinhibitorPP1completelyblockedEGFR,ERK1/2,andAktphosphorylationfollowingH2O2exposure.Incontrast,blockadeo...

    参考资料医源资料库；在线期刊；美国生理学杂志；2004年第287卷第5期
  • UpregulationofArginasebyH2O2ImpairsEndothelium-DependentNitricOxide-MediatedDilationofCoronaryArterioles

    ...】Objective-Overproductionofreactiveoxygenspeciessuchashydrogenperoxide(H2O2)hasbeenimplicatedinvariouscardiovasculardiseases.However,mechanism(s)underlyingcoronaryvasculardysfunctioninducedbyH2O2isunclear.WestudiedtheeffectofH2O2ondilationofcoronaryarteriolestoendothelium-dependentandendothelium-i...

    参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第9期
  • 送药O2O：医药巨头夹缝中成长

    “资本市场凛冬已至。”在各类O2O峰会上，无论是投资人还是创业者，都通过亲身经历得出这一结论。伴随着全球各大股市持续动荡，国内风投愈发谨慎，给当下火热的创业潮泼了一盆冷水。几个月以来，O2O企业融资频次大幅降...

    健康行业资讯；专题；网上药店
  • As2O3对人子宫内膜癌细胞HEC1B皮下移植瘤抗肿瘤作用

    【摘要】　　目的检测不同浓度As2O3对人子宫内膜癌HEC1B细胞裸鼠皮下移植瘤的抗肿瘤作用及对瘤细胞内磷酸化细胞外信号调节蛋白激酶(pERK)表达的影响，进一步探讨As2O3的抗肿瘤机制。方法建立人子宫内膜癌HEC1B细胞...

    参考资料医源资料库；在线期刊；齐鲁医学杂志；2010年第25卷第4期
  • RegulationofXanthineOxidoreductaseProteinExpressionbyHydrogenPeroxideandCalcium

    ...ialxanthineoxidase(XO)levelsaredependentontheNADPHoxidase.WepostulatedthatH2O2maymodulatetheirreversibleconversionofxanthinedehydrogenase(XDH)toXOandsoughttoexaminemechanismsinvolved.MethodsandResults—H2O2(100μmol/L)decreasedbovineaorticendothelialcell(BAEC)XDHproteinexpression,andmetaboliclabeli...

    参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第8期
  • ArsenictrioxideinhibitsnuclearreceptorfunctionviaSEK1/JNK-mediatedRXRphosphorylation

    ...avepreviouslypublishedthat2proventreatmentsforacutepromyelocyticleukemia,As2O3andretinoicacid,canbeantagonisticinvitro.WenowreportthatAs2O3inhibitsligand-inducedtranscriptionoftheretinoicacidreceptor,aswellasothernuclearreceptorsthatheterodimerizewiththeretinoidXreceptor(RXR).As2O3didnotinhibittrans...

    参考资料医源资料库；在线期刊；临床研究杂志；2005年第115卷第10期
  • NeuroprotectiveEffectsof17-EstradiolandNonfeminizingEstrogensagainstH2O2ToxicityinHumanNeuroblastomaSK-N-SHCells

    ...trogens.Inthepresentstudy,weassessedtheprotectiveeffectsofestrogensagainstH2O2-inducedtoxicityinhumanneuroblastomacellsandthepotentialmechanismsinvolvedinthisprotection.Wedemonstratethat17-estradiol(17-E2)increasescellsurvivalagainstH2O2toxicityinhumanneuroblastomacells.17-E2effectivelyreducedlipidp...

    参考资料医源资料库；在线期刊；分子药理学杂志；2006年第68卷第7期
  • As2O3的抗癌机制主要是诱导细胞凋亡和抑制端粒酶活性

    ...授主持完成的黑龙江省自然基金课题——“三氧化二砷(As2O3)对大肠癌细胞系（LS-174T）生长及对端粒酶活性的影响”，证实As2O3对结肠癌细胞系生长有抑制作用，其抗癌机制主要是诱导细胞凋亡和抑制端粒酶活性。因此，“抗端...

    参考资料行业资讯；临床快报；肿瘤相关
  • HydrogenPeroxide

    【摘要】Objective-Wetestedthehypothesisthathydrogenperoxide(H2O2),thedismutatedproductofsuperoxide(O2·-),couplesmyocardialoxygenconsumptiontocoronarybloodflow.Accordingly,wemeasuredO2·-andH2O2productionbyisolatedcardiacmyocytes,determinedtheroleofmitochondrialelectrontransportinthe...

    参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第12期

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