找到3402条结果，用时0.324s
  • CalciumandchloridechannelactivationbyangiotensinII-AT1receptorsinpreglomerularvascularsmoothmusclecells

    ...ta,GeorgiaABSTRACTThepathwaysresponsiblefortherapidandsustainedincreasesin[Ca2+]ifollowingactivationofANGIIreceptors(AT1)inrenalvascularsmoothmusclecellswereevaluatedusingfluorescencemicroscopy.Restingintracellularcalciumconcentration[Ca2+]iaveraged75±9nM.TheresponsetoANGII(100nM)wascharacterizedby...

    参考资料医源资料库；在线期刊；美国生理学杂志；2005年第288卷第8期
  • HumanADPKDprimarycystepithelialcellswithanovel,singlecodondeletioninthePKD1geneexhibitdefectiveciliarypolycystinlocalizationandlossoff

    ...ure.ConfluentNKcellsrespondtoshearstresswithtransientincreasesincytoplasmicCa2+concentration([Ca2+]i),dependentonbothextracellularCa2+andreleasefromintracellularstores.Incontrast,ADPKDcystcellslackflow-sensitive[Ca2+]isignalingandexhibitreducedendoplasmicreticulumCa2+storesandstore-depletion-operate...

    参考资料医源资料库；在线期刊；美国生理学杂志；2007年第290卷第3期
  • 研究发现NO调节花粉管生长过程中胞内外Ca2+变化和细胞壁构建

    ...，同时使花粉管顶端膨大，丧失极性；NO释放剂促进胞外Ca2+内流，顶端Ca2+浓度梯度增加，NO抑制剂抑制胞外Ca2+内流，顶端Ca2+浓度梯度降低；NO释放剂还能够促进囊泡运输，使花粉管顶端的细微丝束解聚，相反，NO抑制剂抑制囊泡...

    参考资料医药经济；生物技术；技术要闻
  • Methylmercury-InducedIncreaseofIntracellularCa2+IncreasesSpontaneousSynapticCurrentFrequencyinRatCerebellarSlices

    ...y-InducedTherelationshipbetweenincreasedintracellularcalciumconcentration([Ca2+]i)andchangesinspontaneoussynapticcurrentfrequencycausedbytheneurotoxicantmethylmercury(MeHg)wasexaminedinPurkinjecellsofcerebellarslicesusingconfocalmicroscopyandwhole-cellrecording.MeHg(10-100µM)stimulatedandthens...

    参考资料医源资料库；在线期刊；分子药理学杂志；2007年第69卷第4期
  • RoleofNitricOxideinCa2+SensitivityoftheSlowlyActivatingDelayedRectifierK+CurrentinCardiacMyocytes

    ...hoolofPharmaceuticalSciences,Funabashicity,Chiba,Japan.　　　SarcolemmalCa2+entryisavitalstepforcontractionofcardiomyocytes,butCa2+overloadisharmfulandmaytriggerarrhythmiasand/orapoptosis.TomaintaintheamountofCa2+entrywithinanappropriaterange,cardiomyocyteshavefeedbacksystemsthattightlyregulateio...

    参考资料医源资料库；在线期刊；循环研究杂志；2005年第95卷第1期
  • Bradykinin-InducedNuclearFactorofActivatedT-Cells-DependentTranscriptioninRatDorsalRootGanglionNeurons

    ...vokedconcentration-dependent(EC50=6.0±0.3nM)increasesinintracellularCa2+concentration([Ca2+]i)inaproportionofdorsalrootganglionneuronsinprimaryculture.These[Ca2+]increasesweresensitivetoinhibitionofphospholipaseC(PLC)anddepletionofCa2+stores.Inneuronsexpressingagreenfluorescentprotein(GFP)-NF...

    参考资料医源资料库；在线期刊；分子药理学杂志；2007年第69卷第8期
  • AngiotensinIICa2+signalinginratafferentarterioles:stimulationofcyclicADPriboseandIP3pathways

    ...naatChapelHill,ChapelHill,NorthCarolinaABSTRACTANGIIinducesariseincytosolicCa2+([Ca2+]i)invascularsmoothmuscle(VSM)cellsviainositoltrisphosphatereceptor(IP3R)activationandreleaseofCa2+fromthesarcoplasmicreticulum(SR).TheCa2+signalisaugmentedbycalcium-inducedcalciumrelease(CICR)andbycyclicadeninediph...

    参考资料医源资料库；在线期刊；美国生理学杂志；2005年第288卷第4期
  • Srcfamilykinaseinvolvementinratpreglomerularmicrovascularcontractileand[Ca2+]iresponsestoANGII

    ...rcontraction.TheeffectofSrckinaseinhibitiononANGII-inducedintracellularfreeCa2+concentration([Ca2+]i)responseswasprobedinfura2-loadedpreglomerularmicrovascularsmoothmusclecells(PVSMCs)obtainedfromexplantsandstudiedafter35daysinculture.InuntreatedPVSMCs,ANGIIevokedpeak(=293±66nM)andplateau(=23±8nM)...

    参考资料医源资料库；在线期刊；美国生理学杂志；2005年第288卷第4期
  • 透明质烷-CD44促进头颈癌中磷脂酶C介导的Ca2+信号传导和顺铂耐受性

    ...系列试验。他们分别在有或无HA，抗CD44抗体和其他PLC介导Ca2+信号通路抑制剂的情况下对接受了化疗药物顺铂处理的肿瘤细胞生长情况进行了观察，并使用Ca2+结合染料Fura/2AM，通过荧光分光光度法Ca2+的流动情况做了记录。结果发...

    参考资料行业资讯；临床快报；肿瘤相关
  • 激光扫描共焦显微镜技术及应用

    ...应用定位、定量三维重组动态测量¨活细胞或组织内游离Ca2+浓度的测量¨活细胞内H+浓度（pH值）的测量¨自由基的检测¨药物进入细胞的动态过程、定位分布及定量应用：细胞膜电位的测量荧光漂白恢复（FRAP）的测量笼锁解笼锁...

    参考资料药品天地；专业药学；实验技术；色谱技术；色谱入门

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