...hamajorhistocompatibilityclassImoleculepresentedbyanantigen-presentingcell(APC).Itseemsthatdendriticcells(DCs)arethepredominantAPCsfortheprimingofnaïveCD8Tcells15-17andforinitiatingCD8memoryT-cellproliferativeresponses.15-18Surprisingly,theroleofdendriticcellshasnotbeenwellstudiedinCOPD.Inmurin...
参考资料医源资料库；在线期刊；美国病理学杂志；2007年第169卷第9期...lls[11].OnepossibletargetsiteforHSVisattheleveloftheantigen-presentingcell(APC).ThemostpotentformofAPCknownisthedendriticcell(DC)[12].SeveralviralinfectionsofDCshavebeenanalyzed,and2mainendpointshavebeenobserved.Inonescenario,DCmaturation(increasedexpressionofMHCandcostimulatorymolecules)occurs,with...
参考资料医源资料库；在线期刊；传染病学杂志；2003年第187卷第2期...ethatduringprimaryTcellactivation,theabsenceofDafonantigen-presentingcells(APCs)andonTcellsenhancesTcellproliferationandaugmentstheinducedfrequencyofeffectorcells.TheeffectisfactorD-and,atleastinpart,C5-dependent,indicatingthatlocalalternativepathwayactivationisessential.WeshowthatcognateTcell–APC...
参考资料医源资料库；在线期刊；实验医学杂志；2005年第201卷第10期...ocompatibilitycomplexclassIImoleculesbyprofessionalantigen-presentingcells(APCs),favoringpresentationofsomepeptidesoverothers.Despiteconsiderableresearchbymanylaboratories,thereisstillsignificantuncertaintyregardingthebiochemicalattributesofclassII–peptidecomplexesthatgoverntheirsusceptibilitytoDM...
参考资料医源资料库；在线期刊；实验医学杂志；2006年第203卷第5期...ice.(D)ConAinducedproliferationofIL-1R+/+CD4+Tcellsonirradiatedsplenocytes(APC)inthepresenceofincreasingnumbersofeitherIL-1R1+/+(blackbars)orIL-1R1-/-(yellowbars)DCs.Oneoutoffourrepresentativeexperimentsisshown.Valuesareexpressedasmean(±SD)offourculturewells. Tofurtherinvestigatethefunctionofauto...
参考资料医源资料库；在线期刊；实验医学杂志；2003年第197卷第3期...ice.(D)ConAinducedproliferationofIL-1R+/+CD4+Tcellsonirradiatedsplenocytes(APC)inthepresenceofincreasingnumbersofeitherIL-1R1+/+(blackbars)orIL-1R1-/-(yellowbars)DCs.Oneoutoffourrepresentativeexperimentsisshown.Valuesareexpressedasmean(±SD)offourculturewells. Tofurtherinvestigatethefunctionofauto...
参考资料医源资料库；在线期刊；美国病理学杂志；2003年第162卷第3期...hiocyanate(FITC),CD4-PerCP-Cy5.5(allBDBiosciences),andCD69-allophycocyanin(APC)(CaltagLaboratories,Burlingame,CA).TheCD4+CD69+IFN-+Tcells(backgroundlevelssubtracted)weredesignatedVZV-specificCD4+Tcells.NegativecontrolsconsistedofCD4+Tcellsstimulatedwithmedium,andpositivecontrolsconsistedofCD4+Tcells...
参考资料医源资料库；在线期刊；微生物临床杂志；2005年第43卷第11期...dwereanti-Thy1.1-PE,anti-Thy1.1-FITC,anti-CD69-biotin,anti-CD4-PE,anti-CD4-APC,andstreptavidin-APC(PharMingen).FluorescentlylabeledcellsweredetectedusingaFACSCalibur(BectonDickinson)withCELLQuestsoftware(version3.3;BectonDickinson).Forhistologicalstudies,lungswerefixedwith10%formalin,andthenthetissu...
参考资料医源资料库；在线期刊；美国病理学杂志；2006年第168卷第5期...ARwasreportedasadownstreamtargetoftheoncogenicWnt/adenomatouspolyposiscoli(APC)/?-cateninpathway(78).Arecentstudydisputesthisconnection,andfurtherstudiestodecipheraroleforPPARincancerhavebeeninconsistent(21,79-82).ExperimentsusingPPAR-nullmicedemonstratedthatPPARisgeneticallydispensableforcolonpolyp...
参考资料医源资料库；在线期刊；临床研究杂志；2006年第116卷第3期...I).PK136-FITCand-PE(anti-NK1.1),anti-CD3-PerCP,anti-Ly49I-FITC,anti-Ly49G2-APC(4D11),anti-Ly49F-PE,anti-KLRG1-biotin(MAFA),anti-Ly49D(4E5),anti-CD16-FITC(2.4G2),anti-CD11b-PE,anti2B4-PE,andIFN-–PEwerepurchasedfromBDBiosciences,andanti-NKG2D-PE(CX5)obtainedfromeBioscience.Anti-Ly49A(YE1/48)hybridom...
参考资料医源资料库；在线期刊；实验医学杂志；2005年第201卷第7期