...ponsetoT3.70andanti-CD28treatment.Inaddition,incubationwithHYpeptide-loadedAPCsdidnotresultinincreasedannexinVstainingaboveAPCcontrolsinthemutants,whereasDPthymocytesfromHY+LAT+/+RAG-2–/–femalemicedidhaveincreasedannexinVstaining.Again,etoposidetreatmentresultedinhighratesofcelldeathinbothHY+LAT...
参考资料医源资料库；在线期刊；实验医学杂志；2005年第201卷第7期...y(day1)phaseofthedisease,anddemonstratedthatitwasmainlytriggeredbyactivatedAPCsandmediatedbyinterferon(IFN)-andtumornecrosisfactor(TNF)-.17Inthecurrentstudy,wefocusedonthemechanismsresponsibleforthelate(day5)phaseofthedisease,anddiscoveredahithertounexpectedroleforactivatedBcellsinthepathogenesisofl...
参考资料医源资料库；在线期刊；美国病理学杂志；2006年第168卷第3期...Cs(IMDCs)promoteTregcellproliferationinvitroandinvivoWenextcharacterizedtheAPCsresidinginlymphoidorgansthatcouldpromotetheproliferationofTregcellsisolatedfromtumorbearinghostsinvitro.TumorcellsthatlackedMHCclassIIexpression(evenafterinvitrostimulationwithTNF-andIFN-;unpublisheddata)couldnotdirectlyi...
参考资料医源资料库；在线期刊；实验医学杂志；2005年第202卷第7期...CD10-enrichedandCD10-depletedBcellfractionswerestainedwithanti–humanCD19-APC,anti–humanCD10-PE,anti–humanIgM-biotin,andanti–humanCD27-FITCantibodies(BDBiosciences),andbiotinylatedanti–humanIgMantibodywasrevealedusingstreptavidin-PeCy7(CaltagLaboratories).NewemigrantBcells(CD19+CD10+IgM+CD2...
参考资料医源资料库；在线期刊；实验医学杂志；2005年第201卷第5期...rotein(PerCP)-conjugatedratanti-mouseCD4(cloneRM4-5,IgG2a),allophycocyanin(APC)-conjugatedratanti-mouseCD8a(clone53-6.7IgG2a),andR-phycoerythrin(R-PE)-conjugatedratanti-mousenaturalkiller(NK)/naturalkillerT(NKT)cellantigen(cloneU5A2-13,IgG2a).U5A2-13mAballowedidentificationofcellpopulationswithaprof...
参考资料医源资料库；在线期刊；美国病理学杂志；2006年第168卷第6期...TcellsexpressingthesameTCRisrelatedtocompetitionforpeptide–MHCcomplexesonAPC(17).Notably,however,competitionwithTcellsthatproliferatedearlierintheresponseonlycauseda2–3-foldreductionintheexpansionpotentialofthelatearrivers.Thus,althoughcompetitionwasarestrainingforceontheactivationofthelatearriv...
参考资料医源资料库；在线期刊；实验医学杂志；2006年第203卷第4期...mdash;Oxidized1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine(Ox-PAPC)anditscomponentphospholipid,1-palmitoyl-2-(5,6epoxyisoprostanoyl)-sn-glycero-3-phosphocholine(PEIPC),whicharepresentinatheroscleroticlesions,activateendothelialcellstoinduceacomplexinflammatoryandpro-oxidantresponse.Previ...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第6期...以激活免疫细胞的树突细胞（DCs）或其他抗原呈递细胞（APCs）作为疫苗。包括DCs在内的APCs摄入癌抗原或被癌抗原基因转染后，经过一系列加工处理过程，将癌抗原信息呈递给淋巴细胞，由此激活免疫细胞对癌细胞的识别和清除...
参考资料行业资讯；临床快报；肿瘤相关...xperimentsincludedanti-CD21/CD35-FITC,anti–CD23-PE,anti-CD138,anti–IgM-APC,anti–IgMa-PE,anti–IgDa-PE,anti-IgMb,andanti–B220-APCoranti-CyChrome(allfromBDBiosciences).Themonoclonalhamsteranti–mouseanti-TCRcoupledtoOregonGreen,Ham-597,wasdescribedpreviously(49).Biotinylatedanti-CD93wasorigi...
参考资料医源资料库；在线期刊；实验医学杂志；2006年第203卷第3期...)mousethatwascreatedbygermlinemutagenesis.ThisresultedinapointmutationintheApctumorsuppressorgeneandahighfrequencyofintestinaltumors.68TheoutcomesfromthisGEMaresimilartopatientswhohavefamilialadenomatouspolyposisandahighfrequencyofintestinaltumors.Overall,GEMshaveseldombeenusedtotestnovelanti-cancer...
参考资料医源资料库；在线期刊；美国病理学杂志；2007年第169卷第3期