...而抗原肽与胞内MHC分子形成复合物，并在抗原提呈细胞（APC）表面呈现，被αβT细胞识别，激发抗肿瘤细胞特异性反应；HSP70还可以促进Th细胞向Thl细胞转化，调整肿瘤患者机体的免疫状态；(2)通过激活CTL(CD8+)细胞杀伤肿瘤细胞；...
参考资料医源资料库；在线期刊；中华医学研究杂志；2006年第6卷第10期...ents),0.4e/mLanti-caveolin-1(sc-894;SantaCruzBiotechnology)0.6e/mLanti-SK3(APC-025;AlomoneLabs)or0.8e/mLanti-hIK1(M2016;providedbyDrD.J.Trezise,GlaxoSmithKline,UK)andthenwithsecondaryantibody(0.04e/mLhorseradishperoxidase-conjugatedgoatanti-mouseforCaSR,orgoatanti-rabbitforcaveolin-1,SK3andIK1;Jacks...
参考资料医源资料库；在线期刊；循环研究杂志；2005年第95卷第8期...sofsuppressionuponactivationinthepresenceofanti-CD3mAbpresentedbyallogeneicAPCs(“weak“TCRstimulus)(Figure4A)orcoatedonbeadstogetherwithanti-CD28mAb(“strong“TCRstimulus)(Figure4B).CD4+CD25highTcellsfromIPEXpatientsandNDswereanergicanddidnotproliferate(Figure4,AandB)orproduceIFN-andTNF-(datano...
参考资料医源资料库；在线期刊；临床研究杂志；2006年第116卷第6期...BectonDickinson)wereused:CD3-FITC,CD27-PEorsIgD-PE,CD19-PerCpCy5.5,andCD38-APC.Ineachexperiment,isotype-andconcentration-matchedcontrolswereused.Datafrom20,000to100,000gatedcells/samplewererecorded,andthepercentpositiveforeachanalyzedmarkerassessedusingtheisotype-matchednegativecontrolsamples.Previo...
参考资料医源资料库；在线期刊；美国病理学杂志；2007年第169卷第9期...indstoCD154onactivatedTcellsandisaninitiatorofthecross-talkbetweenTcellsandAPCs(2,3).CD40actsasamasterregulatorofAPCfunction,inducingDCmaturationandcytokineproduction(4–6),andconsequentlytheinteractionbetweenCD154(CD40-ligand)andCD40iscriticalforthedevelopmentofamatureimmuneresponse.StudiesinCD40K...
参考资料医源资料库；在线期刊；实验医学杂志；2006年第203卷第4期...ionTheengagementofanantigen-specificTCRwiththeMHC/peptidecomplexdisplayedonAPCsprovidesthefirstessentialsignalforTcellactivation.TheseTCR-mediatedsignalsmodulatedbycosignalingmoleculesexpressedonthecellsurfaceresultinaugmentation(costimulation)ofTcellresponses(1-3).SeveralB7familymembershavebeeniden...
参考资料医源资料库；在线期刊；临床研究杂志；2005年第115卷第3期...andcytokineproductionofdendriticcellsDCswerelabeledwithmouseanti-humanCD83-APC(Calteg,Burlingame,CA)andmouseanti-humanCD86-PE(BDPharmingen,SanJose,CA)andsubsequentlyanalyzedwiththeuseofaFACSVantage(FACSscan;BectonDickinson,MountainView,CA).ImmatureDCs(2x104cellsin200µL)werewashedandstimulatedfo...
参考资料医源资料库；在线期刊；美国临床营养学杂志；2004年80卷第6期...ulationincomparisonwithnaiveTcells,whichledtothehypothesisthatanyperipheralAPCexpressingMHCIIcouldstimulateeffectorTh2cells(20–22).ToexaminemoreclearlytheneedforDCsintheinductionandmaintenanceofeffectorTh2responsestoallergenchallenge,wedecidedtodepletethesecellsduringOVAaerosolexposureofOVA-sensit...
参考资料医源资料库；在线期刊；实验医学杂志；2005年第201卷第6期...inalsideoftheendothelialcellwall,andthethrombin-TMcomplexconvertsproteinCtoAPC.APCthenbindstoproteinS(S)onendothelialcellsurfaces.ThecomplexcomposedofproteinSandAPCthenconvertsfactorVaintoaninactivecomplex(VI).ProteinSandAPCalsointeractwiththeendothelialcellproteinCreceptor(EPCR).Bottompanel:Afterin...
参考资料医源资料库；在线期刊；美国病理学杂志；2007年第169卷第5期...eanticoagulantprocess,7,8inwhichitfunctionsasacofactorforactivatedproteinC(APC).9,10Inaddition,proteinSmaydownregulatethecoagulationpathwayindependentlyofAPC.11,12ThenotionthatdeficienciesinproteinSareassociatedwithanincreasedthrombotictendency13,14demonstratesthatappropriateplasmalevelsofproteinSar...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第10期