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  • CD4TcellsintegratesignalsdeliveredduringsuccessiveDCencountersinvivo

    ...reaimedatperiodicallyblockingsignaltransductioninTcellsthatinteractedwithanAPCsupportedtheideathatIFN-productionbyTcellscouldbeinducedbyintermittentsignals(7).Dependingonthesystemused,reexposureofinvitroactivatedCD4TcellstoAgcansustaincellproliferation,promoteIFN-production,orinducecelldeath(8,9).In...

    参考资料医源资料库;在线期刊;实验医学杂志;2005年第202卷第9期
  • ImpairedCXCR4SignalingContributestotheReducedNeovascularizationCapacityofEndothelialProgenitorCellsFromPatientsWithCoronaryArteryDisease

    ...eviously.30CXCR4receptorexpressionwasdeterminedbyanti-humanallophycocyanin(APC)-labeledantibody(BDPharmingen)andanantibodyagainstepitope6H8,whichrecognizesanepitopelocatedbetweenresidues22and25oftheN-terminalextracellulardomainoftheCXCR4receptor(kindlyprovidedbyDr.Arenzana-Seisdesdos,PasteurInstitut...

    参考资料医源资料库;在线期刊;循环研究杂志;2005年第95卷第11期
  • 免疫因素在瘢痕形成中的作用

    ...,DC)是一类重要的专职抗原提呈细胞(Antigen-presentingcells,APC),具有活化幼稚T淋巴细胞的功能,同时自身又高表达主要组织相容性复合体(MHC)Ⅱ类分子。Kohn等[3]使用电子显微镜发现正常表皮内27%的郎格罕细胞接近基底层,65%位于表皮...

    参考资料医源资料库;在线期刊;中华现代临床医学杂志;2012年第10卷第6期
  • ResidentPleuralMacrophagesAreKeyOrchestratorsofNeutrophilRecruitmentinPleuralInflammation

    ...andmouseanti-CD3PE(bothfromPharmingen,SanDiego,CA),andF4/80allophycocyanin(APC)andF4/80PE(bothfromCaltag,BotolphClaydon,UK).Cellnumberwasdeterminedasdescribedpreviously(27).AdoptiveTransferofPleuralCellPopulationsPleurallavagesfromgroupsofnaiveFVB/NWTmicewereincubatedwithPE-conjugatedanti-F4/80antib...

    参考资料医源资料库;在线期刊;美国呼吸和危急护理医学;2006年第173卷第5期
  • ComplementC3aandC4aIncreasedinPlasmaofPatientswithAspirin-inducedAsthma

    ...ysymptoms,nopasthistoryofASAhypersensitivity,anFEV1greaterthan80%predicted,aPC20methacholinegreaterthan25mg/ml,andnormalfindingsonasimplechestradiogram.Allsubjectsgaveinformedconsent,andtheprotocolswereapprovedbythelocalethicscommittees.AspirinChallengeandSeparationofPlasmaOralaspirinchallengewasper...

    参考资料医源资料库;在线期刊;美国呼吸和危急护理医学;2006年第173卷第4期
  • R-Cadherin:?-CateninComplexandItsAssociationWithVascularSmoothMuscleCellProliferation

    ...mamembraneortargetedforproteosomaldegradationbytheadenomatouspolyposiscoli(APC),Axin,andglycogensynthasekinase3?(GSK3?)complex.However,inthepresenceofWntsignaling,theAPC-Axin-GSK3?complexisinhibitedbecauseofinactivationofGSK-3?byWnt.Thisresultsinincreasedfreecytoplasmic?-catenin,whichtranslocatestot...

    参考资料医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第7期
  • SelectivedysregulationoftheFcIIBreceptoronmemoryBcellsinSLE

    ...armLyse(BectonDickinson).Cellswereincubatedwiththefollowingantibodies:CD19-APC,CD27-PE(Caltag),anti-FcRIIB(asdescribedinthepreviousparagraph),mouseIgG1controlantibody,andgoatanti–mouseIgG1(BDBiosciences).FlowcytometryfortheSLEsubjectsandthecontrolAgroupwasperformedwithaFACSCalibur(BectonDickinson)...

    参考资料医源资料库;在线期刊;实验医学杂志;2006年第203卷第9期
  • RoleofProteaseActivatedReceptor1and2SignalinginHypoxia-InducedAngiogenesis

    ...sofvascularobliterationandneovasculartuftswerequantifiedfromthesemontages.NAPc2,NAP5,andImatinibTreatmentImmediatelyafterreturntonormoxiaatdayP12,miceweretreatedwithintraperitonealinjectionsofNAPc2(1mg/kg)orascontrolswitheitherbufferornonreactiveantibody.DosingwasoncedailyuntilsacrificeatdayP17.NAP5...

    参考资料医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第6期
  • 复方醋酸环丙孕酮片

    ...形成的遗传或获得性的生物化学因素,包括活化蛋白C(APC)抵抗,高半胱氨酸血症,抗凝血酶缺乏,蛋白C缺乏,蛋白S缺乏,抗磷脂抗体(抗心肌磷脂抗体,狼疮抗凝剂)。当权衡利弊时,医生应考虑到对一种病情的适当治疗可...

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  • ReceptortyrosinekinasesmediateepithelialNa+channelinhibitionbyepidermalgrowthfactor

    ...athperfusion(1ml/min)withadeadtimeof1020s.CurrentrecordingswereacquiredwithaPC505Bpatch-clampamplifier(WarnerInstruments)interfacedviaaDigidata1322A(AxonInstruments)toaPCrunningthepClamp9suiteofsoftware(AxonInstruments).Forexcisedpatches,gap-freecurrentrecordingsweremadeat0mV.Forwholecellexperiments...

    参考资料医源资料库;在线期刊;美国生理学杂志;2005年第288卷第1期

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