【摘要】Objective—Severalplateletproteinsarepalmitoylated,butwhetherproteinpalmitoylationfunctionsinplateletactivationisunknown.Wesoughttodeterminetheroleofplateletproteinpalmitoylationinplateletactivationandthrombusformation.MethodsandResults—Plateletproteinsweredepalmitoylatedbyinf...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第6期【摘要】Background-InhibitionofGPVIhasbeenproposedasausefulantithromboticstrategy;however,invivoproof-of-conceptanimalstudiestargetingGPVIarelacking.Weevaluatedanovelanti-humanGPVImonoclonalantibodyOM4Fabinrats.MethodsandResults-OM4Fabspecificallyinhibitedcollagen-inducedaggregationofratplatelet...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第5期【摘要】Objective—HSP60-specificTcellscontributetothedevelopmentoftheimmuneresponsesinatherosclerosis.ThiscanbedampenedbyregulatoryTcellsactivatedviaoraltoleranceinduction,andweexploredtheeffectoforaltoleranceinductiontoHSP60andthepeptideHSP60(253to268)onatherosclerosis.MethodsandResults&m...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第12期FromtheDepartmentPhysiologyandPharmacology(J.O.L.),KarolinskaInstitutet,andtheDepartmentofSurgicalScience(E.W.),KarolinskaUniversityHospital,Stockholm,Sweden.CorrespondencetoJonLundberg,Professor,DepartmentofPhysiologyandPharmacology,KarolinskaInstitutet,17177Stockholm,Sweden.E-mailjon.lundberg@fyfa...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第5期【摘要】Background-Wehaverecentlydemonstratedthatactivityofredbloodcellglutathioneperoxidase-1isinverselyassociatedwiththeriskofcardiovasculareventsinpatientswithcoronaryarterydisease.Thepresentstudyanalyzedtheeffectofglutathioneperoxidase-1deficiencyonatherogenesisintheapolipoproteinE-deficient...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第4期FromDepartmentofPathologyandMedicine,ExperimentalandClinical,UniversityofUdine,Italy.ABSTRACTType2diabetesisaworldwideincreasingdiseaseresultingfromtheinteractionbetweenasubject’sgeneticmakeupandlifestyle.Ingeneticallypredisposedsubjects,thecombinationofexcesscaloricintakeandreducedphysicalactivit...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第5期【摘要】Objective-Wetestedthehypothesisthathydrogenperoxide(H2O2),thedismutatedproductofsuperoxide(O2·-),couplesmyocardialoxygenconsumptiontocoronarybloodflow.Accordingly,wemeasuredO2·-andH2O2productionbyisolatedcardiacmyocytes,determinedtheroleofmitochondrialelectrontransportinthe...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第12期【摘要】Objective-Theroleofcholesterylestertransferprotein(CETP)inthedevelopmentofatherosclerosisisstillundergoingdebate.Therefore,weevaluatedtheeffectofhumanCETPexpressiononatherosclerosisinAPOE*3-Leiden(E3L)micewithahumanizedlipoproteinprofile.MethodsandResults-E3LmicewerecrossbredwithhumanCET...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第11期【摘要】Nitricoxide(NO)isamultifunctionalbiomoleculeinvolvedinavarietyofphysiologicalandpathologicalprocesses,includingregulationofbloodvesseldilatationandanti-arterioscleroticeffects.However,alargeamountofNOistoxictothehostandcausesseveraldiseasessuchasapoptosis,septicshock,anddiabetesmellitus....
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第7期FromtheDepartmentofCardiovascularMedicine,UniversityofOxford,JohnRadcliffeHospital,Oxford,UnitedKingdom.CorrespondencetoProfessorK.M.Channon,DepartmentofCardiovascularMedicine,UniversityofOxford,JohnRadcliffeHospitalOxfordOX39DUUnitedKingdom.E-mailkeith.channon@cardiov.ox.ac.ukAbstractNitricoxide(NO...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第3期