找到970条结果，用时0.386s
您是不是想找:
  • 结肠癌的流行病学及其危险因素的研究

    ...主要是发现在腺瘤结肠息肉病患者中有超过半数的患者有APC基因变异，不能正常发挥作用。而同样这一基因在超过1/3的乳腺癌患者中也存在同样的基因变异。　　2.2.6高甘油三酯血症　　日本研究者所做的一项大规模的回顾性研...

    参考资料医源资料库；在线期刊；中华现代临床医学杂志；2006年第4卷第11期
  • 单核细胞激活及Th1/Th2细胞因子的变化与肾综合征出血热病情的关系

    ...此与IL-12分泌增加不无相关。IL-12主要由抗原提呈细胞（APC）所合成,能刺激T细胞和自然杀伤细胞（NK）产生INFγ，促进Th0向Thl分化；而INFγ也能刺激抗原提呈细胞分泌IL-12，进一步促进Thl细胞的极化,故而在IL-12与INFγ之...

    参考资料医源资料库；在线期刊；中华中西医杂志；2007年第8卷第8期
  • TheN-terminaldomainofthrombomodulinsequestershigh-mobilitygroup-B1protein,anovelantiinflammatorymechanism

    ...coagulantcofactorthatpromotesthrombin-mediatedformationofactivatedproteinC(APC).WehavefoundthattheN-terminallectin-likedomain(D1)ofTMhasuniqueantiinflammatoryproperties.TM,viaD1,bindshigh-mobilitygroup-B1DNA-bindingprotein(HMGB1),afactorcloselyassociatedwithnecroticcelldamagefollowingitsreleasefromt...

    参考资料医源资料库；在线期刊；临床研究杂志；2005年第115卷第5期
  • DirectinvivoVHtoJHrearrangementviolatingthe12/23rule

    ...ingwasperformedasdescribedpreviously(18).AntibodieswereconjugatedtoFITC,PE,APC,PerCP,Cy-Chrome,orbiotin.BiotinylatedantibodiesweredevelopedwithstreptavidinconjugatedtoCy-ChromeorPerCP.StainedcellswereanalyzedonaFACScalibur(BectonDickinson).Cellsortingwasperformedusingatriplelaserflowcytometer(FACSVa...

    参考资料医源资料库；在线期刊；实验医学杂志；2005年第201卷第3期
  • Lactosedoesnotenhancecalciumbioavailabilityinlactose-tolerant,healthyadults

    ...sandreproducibility.BrJPharmacol1996;41:543–9.TranswellP,KoupJ,Topfit.APC-basedpharmacokinetic/pharmacodynamicdataanalysisprogram.IntJPharmacolTherToxicol1993;31:514–20.SipsAJAM,BartoR,NetelenbosJC,vanderVijghWJF.Preclinicalscreeningoftheapplicabilityofstrontiumasamarkerforintestinalcalciu...

    参考资料医源资料库；在线期刊；美国临床营养学杂志；2000年71卷第4期
  • 李金名：肿瘤标志物的临床应用、问题及思考

    ...病毒（HBV）等；基因如BRCA1/BRCA2遗传性乳腺癌相关基因、APC基因（家族性腺瘤样息肉病筛查）和微卫星不稳定性（MSI，用于遗传性非息肉性结肠癌筛查）；基因结构变化如kRAS和上皮生长因子受体（EGFR）基因突变与结直肠癌和非...

    参考资料行业资讯；临床快报；肿瘤相关
  • WhereCD4+CD25+Tregcellsimpingeonautoimmunediabetes

    ...ntoTeffcellsubsets;inducinganergyinpathogenicTcells;modulatingthefunctionofAPCs;inhibitingmemoryTcellaccumulation;andgenerallyrestraininginflammatorypathology(10,12,22,23).However,mostinvivostudiesofTregcellstodatehaveusedexperimentalsystemswheretheyweretransferred,togetherwitheffectorcells,intolymp...

    参考资料医源资料库；在线期刊；实验医学杂志；2005年第202卷第10期
  • RepeatedstimulationofCD4effectorTcellscanlimittheirprotectivefunction

    ...ectiveadaptiveimmuneresponsedependsonsuccessfulinteractionsbetweenTcellsandAPCs.WhennaiveCD4Tcellssuccessfullyrecognizeantigen(Ag)thatispresentedbyAPCs,theyexpandintohighlyactivatedeffectorsthatexhibitimmediatecytokine-secretingfunction(1–3).WehypothesizethatreachinganoptimalthresholdofTCRstimulat...

    参考资料医源资料库；在线期刊；实验医学杂志；2005年第201卷第7期
  • Kruppel-LikeFactor2InhibitsProteaseActivatedReceptor-1ExpressionandThrombin-MediatedEndothelialActivation

    ...wasfromAmericanDiagnostica,and-tubulinantibodywasfromSigma.Allophycocyanin(APC)-conjugatedanti-mouseantibodywaspurchasedfromCaltag.AlladenoviralconstructsweregeneratedbytheHarvardGeneTherapyInitiative.NorthernandWesternBlotAnalysisandELISAAssayHUVECswereinfectedwithadenovirusencodinggreenfluorescent...

    参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第5期
  • TypeIinterferondependenceofplasmacytoiddendriticcellactivationandmigration

    ...egalovirus;pDC,plasmacytoiddendriticcell;TLR,Toll-likereceptor.DCsarepotentAPCsthatinitiateTcell-dependentimmuneresponses(1).Afterexposuretoavarietyofinflammatorystimuli,includingligandsforToll-likereceptors(TLRs;reference2),DCsundergophenotypicandfunctionalchangesthatcharacterizetheirtransitionfrom...

    参考资料医源资料库；在线期刊；实验医学杂志；2005年第201卷第7期

相关搜索：

筛选