【摘要】Objective-High-densitylipoprotein(HDL)playsakeyroleinprotectionagainstdevelopmentofatherosclerosisbyreducinginflammation,protectingagainstLDLoxidation,andpromotingreversecholesteroltransportfromperipheraltissuestotheliverforsecretionintobile.Cholesterol7-hydroxylase(Cyp7a1)catalyzesthera...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第12期【摘要】Objective-ThecapacityofhumanC-reactiveprotein(CRP)toactivate/regulatecomplementmaybeanimportantcharacteristicthatlinksCRPandinflammationwithatherosclerosis.RecentadvancessuggestthatinadditiontoclassicalpentamericCRP,aconformationallydistinctisoformofCRP,termedmodifiedormonomericCRP(mCRP)...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第4期【摘要】Objective-Lysophosphatidylcholineisamajorproductoflow-densitylipoprotein(LDL)oxidationandsecretoryphospholipaseA2-mediatedlipidhydrolysiswithinatheroscleroticlesions.TheG2AreceptormediateschemotaxisofculturedmacrophagesandTcellstolysophosphatidylcholine,supportingapro-atherogenicrolefort...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第12期【摘要】Objectives-Extracellularsuperoxidedismutase(ecSOD)lowerssuperoxideanionsandmaintainsvascularnitricoxidelevel.WestudiedthefunctionofecSODinhigh-volumehypertensioninducedbythe1-kidney-1-clipmodelinwild-type,ecSOD-/-mice,andendothelialnitricoxidesynthase(eNOS)-/-mice.MethodsandResults-The1-...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第3期【摘要】Objective-Lipid-loadedmacrophage-derivedfoamcellspopulateatheroscleroticlesionsandproducemanypro-inflammatoryandplaque-destabilizingfactors.Anexcessiveaccumulationofextensivelyoxidizedlow-densitylipoprotein(OxLDL)orfreecholesterol(FC),bothofwhicharebelievedtobemajorlipidcomponentsofmacro...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第5期【摘要】Objective-NaturallyoccurringCD4+CD25+regulatoryTcells(Tregs)exertsuppressiveeffectsoneffectorCD4cellsanddownregulateexperimentalautoimmunedisorders.WeinvestigatedtheimportanceandpotentialroleofTregsinmurineatherogenesis.MethodsandResults-Tregswereinvestigatedcomparativelybetweenagedandyo...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第4期FromLipoproteinandAtherosclerosisResearchGroupDivisionofCardiology,UniversityofOttawaHeartInstitute,Ottawa,Canada.AddresscorrespondencetoRuthMcPherson,UniversityofOttawaHeartInstitute,H453,40RuskinSt,Ottawa,ONCanadaK1Y4W7.E-mailrmcpherson@ottawaheart.caAbstractObjective—Todeterminewhethercholester...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第10期【摘要】Objective—Atherosclerosisisnowconsideredasachronicinflammatorydisease,andinflammationiscloselyrelatedtoimmunesystems,whichconsistofinnate-immunityandadaptive-immunity.Recently,toll-likereceptors(TLRs)havebeenidentifiedaskeycomponentsofinnate-immunity.Weexaminedtheroleoflocalexpress...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第11期【摘要】Itiswellknownthathumanswithdiabeteshavemoreatherosclerosisanditscomplications.Thecausesofthisrelationshipare,however,unclear.Althoughrecentdatashowthatimprovedglycemiccontrolreducesarterialdiseaseintype1diabetes,otherstudieshaveshownthatsubjectswithprediabeteshavemorecardiovasculardiseas...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第8期FromtheDepartmentofMedicalBiochemistry(M.H.,M.S.,K.F.,Y.S.,H.H.,A.M.,S.H.),theFirstDepartmentofInternalMedicine(M.H.,Y.S.),andtheDepartmentofCellPathology(Y.K.,M.T.),GraduateSchoolofMedicalandPharmaceuticalSciences,KumamotoUniversity,Kumamoto,Japan;theDepartmentofAnalyticalChemistry(H.H.),SchoolofPh...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第9期