【摘要】Objective—AorticcalcificationisprevalentintypeIIdiabetes(T2DM),enhancingmorbidityandtrackingmetabolicsyndromeparameters.Ldlr–/–micefedhigh-fatWesternizeddiets(HFD)accumulateaorticcalciumprimarilyinthetunicamedia,mediatedviaosteogenicmorphogensandtranscriptionalprogramst...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第12期FromtheWallenbergLaboratoryforCardiovascularResearch(C.F.,M.G.,J.B.),TheSahlgrenskaAcademyatG?teborgUniversity,G?teborg,Sweden;theGladstoneInstituteofCardiovascularDisease(R.E.P.,L.A.),CardiovascularResearchInstituteandtheDepartmentofPathology(R.E.P.),UniversityofCalifornia,SanFrancisco;andtheDepart...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第3期【摘要】Tetrahydrobiopterin(BH4)isanessentialcofactorforthearomaticaminoacidhydroxylases,whichareessentialintheformationofneurotransmitters,andfornitricoxidesynthase.Itispresentlyusedclinicallytotreatsomeformsofphenylketonuria(PKU)thatcanbeamelioratedbyBH4supplementation.Recentevidencesupportspo...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第11期FromtheDepartmentofMedicalGenetics(C.J.D.R.,G.L.,K.J.D.A.E.,S.M.E.L.,M.R.H.),UniversityofBritishColumbia,CentreforMolecularMedicineandTherapeutics,Vancouver,Canada;theDepartmentofExperimentalVascularMedicine(J.A.K.,J.R.,W.v.D.,J.J.K.),UniversityofAmsterdam,AcademicMedicalCenter,theNetherlands;Amster...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第10期【摘要】Objective—Lipoprotein-associatedphospholipaseA2(Lp-PLA2)isapredictorforincidentatheroscleroticdisease.Weinvestigatedtheeffectof3hypolipidemicdrugsthatexerttheiractionthroughdifferentmechanismsonplasmaandlipoprotein-associatedLp-PLA2activityandmass.MethodsandResults—In50patien...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第10期【摘要】Objective—Obesityisamajorriskfactorforatherosclerosisandisassociatedwithincreasedcardiovascularmorbidityandmortality.However,theprecisemolecularpathwaysresponsibleforthiscloseassociationremainpoorlyunderstood.MethodsandResults—Inthisstudy,wereportthatleptin-deficiency(ob/ob)i...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第12期FromtheAcademicUnitofMolecularVascularMedicine,FacultyofMedicineandHealth,UniversityofLeeds,Leeds,UK.ABSTRACTTheformationofafibrinclotisoneofthekeyeventsinatherothromboticvasculardisease.Thestructureofthefibrinclotandthegeneticandenvironmentalfactorsthatmodifyithaveeffectsonitsbiologicalfunction.Alt...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第9期【摘要】Background-Wehaverecentlydemonstratedthatactivityofredbloodcellglutathioneperoxidase-1isinverselyassociatedwiththeriskofcardiovasculareventsinpatientswithcoronaryarterydisease.Thepresentstudyanalyzedtheeffectofglutathioneperoxidase-1deficiencyonatherogenesisintheapolipoproteinE-deficient...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第4期【摘要】Objective-Plasmahigh-molecular-weightkininogen(HK)iscleavedininflammatorydiseasesbykallikreintoHKawithreleaseofbradykinin(BK).WepostulatedadirectlinkbetweenHKaandcytokine/chemokinerelease.MethodsandResults-HKa,butnotBK,releasescytokinestumornecrosisfactor(TNF)-,interleukin(IL)-1ß,I...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第10期...经系统疾病，产妇高热、器官衰竭等以及原发性高血压、动脉硬化、妊娠高血压综合征等在产程中血压升高，子痫或先兆子痫等需缩短第二产程者。6．吸引器助产失败，确认为无明显头盆不称或胎头已入盆甚至已通过坐骨棘平...
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