【摘要】Objective-TheprotectiveeffectofNOsynthase-3(eNOS)-derivedNOinlimitingmyocardialischemia-reperfusion(MI-R)injuryiswellestablished.WereportedpreviouslythatsystemicgeneticoverexpressionofeNOSattenuatesMI-Rinjury.Thepurposeofthecurrentstudywastoinvestigatetissue-specificgeneticoverexpression...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第7期【摘要】Objective-Thrombinactivatablefibrinolysisinhibitor(TAFI)attenuatesfibrinolysis.TheaimofthepresentstudywastoinvestigatethepossibleassociationbetweenTAFIandoverallischemicstrokeandischemicstrokesubtypes.MethodsandResults-TheSahlgrenskaAcademyStudyonIschemicStroke(SAHLSIS)comprises600cases(...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第4期【摘要】Objective—Proliferationandmigrationofvascularsmoothmusclecells(VSMCs)arestrikingfeaturessharedbyvascularageing,atherosclerosis,andin-stentrestenosis.VSMCbiologydependsinpartonpolyamineswhosemetabolismiscloselyregulatedbyornithinedecarboxylaseantizyme1(OAZ1).Therefore,wesoughtforass...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第10期【摘要】HeparincofactorII(HCII)hasseveralbiochemicalpropertiesthatdistinguishitfromotherserpins:(1)itspecificallyinhibitsthrombin;(2)themechanismofinhibitioninvolvesbindingofanacidicdomaininHCIItothrombinexositeI;and(3)therateofinhibitionincreasesdramaticallyinthepresenceofdermatansulfatemolecul...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第3期【摘要】Objective-Adiponectinisadipose-specificsecretoryproteinandactsasanti-diabeticandanti-atheroscleroticmolecule.Wepreviouslyfoundperoxisomeproliferatorsresponseelementinadiponectinpromoterregion,suggestingthatperoxisomeproliferator-activatedreceptor(PPAR)ligandselevateadiponectin.Fibratesar...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第3期【摘要】Background-ATP-bindingcassettetransporterA1(ABCA1)isakeymediatorofcholesteroleffluxtoapoA-Iincholesterolloadedmacrophages,afirststepofreversecholesteroltransport(RCT)invivo.Macrophagespecificabca1inactivationoroverexpression,respectively,acceleratedorsuppressedthedevelopmentofatheroscler...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第8期FromtheDepartmentsofCardiology(S.M.B.)andVascularMedicine(T.T.K.,J.J.P.K.),AcademicMedicalCenter,Amsterdam,TheNetherlands;MedicalResearchCouncilEpidemiologyUnit(N.J.W.),Cambridge,theDepartmentofPublicHealthandPrimaryCare(R.L.,N.E.D.,M.S.S.,K.T.K.),InstituteofPublicHealth,UniversityofCambridge,andthe...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第4期【摘要】Objective-MacrophageexpressionofbothapolipoproteinE(apoE)andABCA1havebeenshowntomodulatelipideffluxfromthesecellsandtoplayanimportantatheroprotectiveroleinvivo.WeevaluatedtherelationshipbetweenapoEandABCA1forregulatingcellularsterolefflux.MethodsandResults-ApoE-mediated,butABCA1-independ...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第1期【摘要】Objective-ActivationoftranscriptionfactorNF-Bisanimportantstepinthedevelopmentofvasculardamage,becauseitcontrolsinduciblegenes,includingmanyinflammatorymediators.Thepharmacologicalmodulationofthisprocessisthemainobjectiveinthedesignofnewtherapiesforatherosclerosis.Inthisworkweanalyzedthe...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第8期FromINSERMU525(D.-A.T.,V.N.,O.P.,L.T.,F.C.),Paris,France;FunctionalGenomic(S.R.,I.A.,S.S.,M.R.,N.D.,S.M.,P.D.,J.-F.D.),Aventis-SA,EvryandVitrys/Seine,France;Queen’sUniversityBelfast(F.K.,A.E.),NorthernIreland,UnitedKingdom;andtheMonicaProject(C.M.),GlasgowRoyalInfirmary,Scotland,UnitedKingdom.ABST...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第4期