FromtheNephrologyandHypertensionSection(E.A.J.,R.-X.T.),VeteransAffairsMedicalCenter,Miami,Fla.;theResearchSection(E.G.D.),VeteransAffairsMedicalCenter,Minneapolis,Minn.;andtheRenalDivisionandVascularBiologyInstitute(E.A.J.,L.R.),UniversityofMiami,Fla.ABSTRACTObjective—Endothelialdysfunctionisanea...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第6期FromBHFLaboratories,DepartmentofMedicine,UniversityCollegeLondon,UnitedKingdom.ABSTRACTObjective—Thisstudyaimstodeterminetheeffectsofperiadventitialvascularendothelialgrowthfactor(VEGF)genetransferonneointimaformationandmacrophageaccumulationinducedbycollarplacementaroundthecarotidarteryinhypercho...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第6期【摘要】Objective-Hypercholesterolemiaelicitsaproinflammatoryandprothrombogenicphenotypeinthemicrovasculaturethatischaracterizedbyactivationandadhesionofbloodcells.TheangiotensinIIreceptor-1antagonistLosartanpreventstheinductionoftheseresponses.Theobjectiveofthisstudywastodeterminetherelativecon...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第2期【摘要】Objective-UremiaacceleratesatherosclerosisinapolipoproteinE-deficient(apoE-/-)mice.Weexaminedwhetherthiseffectmaybepreventablebypharmacologicalblockadeoftherenin-angiotensinsystem(RAS).MethodsandResults-UremiawasinducedinapoE-/-miceby5/6nephrectomy(NX).Treatmentwiththeangiotensinconverti...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第5期【摘要】Objective-Advancesinstenttechnologyhaveenabledthedeliveryofdrugstoimproveoutcomesafterstentdeployment.However,theoptimalpayloadsforstentsarenotclear,andtheappropriatestent-basedtherapiesforhigh-riskpatients,suchasdiabetics,havenotbeenclearlyestablished.MethodsandResults-Weusedsmoothmuscl...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第7期【摘要】Objective-Theproproteinconvertasesubtilisin/kexintype9(PCSK9)geneencodesaproproteinconvertasethatcausesdegradationofcellsurfacelow-densitylipoproteinreceptors(LDLRs).MutationsinthePCSK9genethatdisruptthenormalfunctionofPCSK9couldthereforeresultinincreasednumberofLDLRsandhypocholesterolem...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第5期【摘要】Objectives-Whereaspostprandialhyperlipidemiaisawell-describedfeatureofinsulin-resistantstatesandtype2diabetes,nopreviousstudieshaveexaminedintestinallipoproteinproductionrates(PRs)inrelationtohyperinsulinemiaorinsulinresistanceinhumans.MethodsandResults-ApolipoproteinB-48(apoB-48)-contai...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第6期【摘要】Background-Prostacyclin(PGI2)andthromboxane(TxA2)effectdisparateoutcomesforatherogenesisandtheresponsetovascularinjury;PGI2,avasodilatorandinhibitorofplateletaggregation,limitsthedeleteriousactionsofTxA2,avasoconstrictorandplateletactivator.DimerizationoftheirGprotein-coupledreceptors,IP...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第2期【摘要】Objective-Atherosclerosisisassociatedwithimmuneresponsestooxidizedlow-densitylipoprotein(oxLDL).ThepresenceofactivatedmacrophagesandTcellsinlesionssuggeststhatcell-mediatedimmunereactionsaretakingplaceduringthediseaseprocess.However,theroleofspecificimmuneresponseshasremainedunclear.Weha...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第4期FromtheDepartmentofImmunology,TheScrippsResearchInstitute,LaJolla,Calif.CorrespondencetoGourabBhattacharjee,EdgingtonLaboratory,TheScrippsResearchInstitute,SP258,LaJolla,CA92037.E-mailgourab@scripps.eduAbstractObjective—TotestthehypothesisthatGrp78negativelyregulatescellsurfacetissuefactor(TF)proc...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第8期