【摘要】Objective-AngiotensinII(AngII)disruptstheregulationofthecerebralcirculationthroughsuperoxide,areactiveoxygenspecies(ROS)generatedbyanox2-containingNADPHoxidase.WetestedthehypothesisthatAngII-derivedsuperoxidereactswithnitricoxide(NO)toformperoxynitrite,which,inturn,contributestothevascul...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第2期【摘要】Objective-Plasminisakeyenzymeinfibrinolysis.Weattemptedtodeterminethepossibleroleofplasminintheregulationofvasculartone,whilealsoinvestigatingthemechanismofplasmin-inducedvasorelaxation.MethodsandResults-Inporcinecoronaryartery,plasmininducedanendothelium-dependentrelaxation.Thisrelaxing...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第4期【摘要】Objective-Thevascularendotheliumconstitutesahighlyeffectivefluid/solutebarrierthroughtheregulatedappositionofintercellulartightjunctioncomplexes.Becauseendothelium-mediatedfunctionsandpathologyaredrivenbyhemodynamicforces(cyclicstrainandshearstress),wehypothesizedadynamicregulatorylinkbe...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第1期【摘要】Objective-Biologicallysignificantamountsoftwoprocoagulantmolecules,phosphatidylserine(PS)andtissuefactor(TF),aretransportedbymonocyte/macrophage-derivedmicrovesicles(MVs).Becausecellularcholesterolaccumulationisanimportantfeatureofatheroscleroticvasculardisease,wenowexaminedeffectsofchol...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第2期【摘要】Objective-Percutaneouscoronaryintervention(PCI)iscurrentlythemostwidelyacceptedtreatmentforacutemyocardialinfarction(AMI).Itremainsunclear,however,whetherpost-AMIconditionsmightexacerbateneointimalhyperplasiaandrestenosisfollowingPCI.Giventhatbothamedialsmoothmusclecelllineageandabonemar...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第9期【摘要】Background-Themetabolicsyndromeistypifiedbyobesity,dyslipidemia,diabetes,hypertension,increasedoxidativestress,andacceleratedatherosclerosis.Paraoxonase1(PON1),ahigh-densitylipoprotein(HDL)-associatedantioxidantenzymethatpreventstheoxidationoflow-densitylipoprotein(LDL),islowinthemetabol...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第7期【摘要】Objective-Thesphingosine-1-phosphate(S1P)analogueFTY720isapotentimmunosuppressiveagentcurrentlyinPhaseIIIclinicaltrialsforkidneytransplantation.FTY720trapslymphocytesinsecondarylymphoidorganstherebypreventingtheirmigrationtoinflammatorysites.Previously,wehaveidentifiedFTY720asapotentacti...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第3期FromRheumatology/Medicine,VeteransAffairsMedicalCenter/UniversityofCaliforniaatSanDiego,SchoolofMedicine.CorrespondencetoRobertTerkeltaub,111K,VeteransAffairsMedicalCenter,3350LaJollaVillageDr,SanDiego,CA92161.E-mailrterkeltaub@ucsd.eduAbstractObjective—Werecentlylinkedhumanarterialmediacalcificat...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第4期【摘要】Objective-Oxidativestresscontributestothepathogenesisofmanydiseases,includingatherosclerosisandsepsis.Wehavepreviouslydescribedanovelclassoftherapeuticcompoundswithantioxidantandantiinflammatoryproperties.However,atpresent,theintracellulartargetsofthesecompoundshavenotbeenidentified.Thep...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第8期【摘要】Objective-Inadditiontotheirroleinprogrammedcelldeath,cellsurvival,andcellgrowth,sphingolipidmetabolitessuchasceramide,sphingosine,andsphingosine-1-phosphatehavevasoactiveproperties.Besidestheiroccurrenceinblood,theycanalsobeformedlocallyinthevascularwallitselfinresponsetoexternalstimuli....
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第9期