【摘要】Objective-TheregulationofAMP-activatedproteinkinase(AMPK)isimplicatedinvascularbiologybecauseAMPKcanphosphorylateendothelialNOsynthase(eNOS).Inthisstudy,weinvestigatetheregulationoftheAMPK-eNOSpathwayinvascularendothelialcells(ECs)byshearstressandtheactivationofaorticAMPKinamousemodelwit...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第6期【摘要】Objective-Carbamylatedlow-densitylipoprotein(LDL),themostabundantmodifiedLDLisoforminhumanblood,hasbeenrecentlyimplicatedincausingtheatherosclerosis-proneinjuriestoendothelialcellsinvitroandatherosclerosisinhumans.ThisstudywasaimedattestingthehypothesisthatcarbamylatedLDLactsviainducingm...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第4期FromBristolHeartInstitute(E.K.,C.A.B.,S.C.S.,G.B.-N.,S.J.G.),BristolRoyalInfirmary,Bristol,UK;AdherexTechnologiesInc(O.W.B.),Ottawa,Ontario,Canada;andtheDivisionofUrology(O.W.B.),DepartmentofSurgery,McGillUniversity,Montreal,Quebec,Canada.CorrespondencetoDrSarahJaneGeorge,BristolHeartInstitute,Level...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第5期【摘要】Objective-Theeffectofanovelsmallmoleculeplasminogenactivatorinhibitor(PAI-1)inhibitoronadiposetissuephysiologywasinvestigated.MethodsandResults-Inhumanpreadipocytecultures,PAI-039inhibitedbothbasalandglucose-stimulatedincreasesinactivePAI-1antigen,yethadnoeffectonPAI-1mRNA,suggestingadir...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第10期【摘要】Objective-ABCG1hasrecentlybeenidentifiedasafacilitatorofcholesterolandphospholipideffluxfrommacrophagestoHDL.Inbonemarrowtransplantationstudies,weandothershavenowshownthattheabsenceofmacrophageABCG1maydifferentiallyinfluenceatheroscleroticlesionsdependentontheexperimentalsettingand/orthe...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第3期FromtheDepartmentofCardiovascularMedicine(R.G.,J.S.,H.K.,T.K.,M.I.),TokyoMedicalandDentalUniversity,Tokyo,Japan;PharmaceuticalFrontierResearchLaboratories(S.S.),JTInc,Yokohama,Japan;andtheDepartmentofMedicalBiochemistry(M.Y.),TokyoMedicalandDentalUniversity,Tokyo,Japan.ABSTRACTObjective—Inflammati...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第11期Abstract：TopAbstractIntroductionMethodsResultsDiscussionReferences：Objective—Arecentstudyidentifiedanewclassofcompoundsdesignatedasthesterol-regulatoryelementbindingprotein(SREBP)cleavage-activatingprotein(SCAP)ligandsthatputativelybindtoSCAP,leadingtoincreasedLDLreceptor(LDLR)expression.Inthi...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2003年第23卷第1期FromtheGraduateInstituteofRehabilitationScienceandCenterforGerontologicalResearch(J.-S.W.,Y.-S.L.,Y.-W.C.),ChangGungUniversity,Taoyuan,Taiwan;DepartmentofPharmacology(J.-C.C.),ChangGungUniversity,Taoyuan,Taiwan.CorrespondencetoJong-ShyanWang,GraduateInstituteofRehabilitationScience,ChangGungUniversi...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第2期【摘要】Objective-Excessironmayincreaseoxidativestressandplayaroleinvascularinflammationandatherosclerosis.Herewedeterminedwhethertheironchelator,desferrioxamine(DFO),amelioratesoxidativestressandcellularadhesionmoleculeexpressioninamurinemodeloflocalinflammation.MethodsandResults-Dorsalairpouch...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第12期【摘要】Objectives—Thepurposeofthisstudywastoidentifygeneticvariantsassociatedwithseverecoronaryarterydisease(CAD).MethodsandResults—Weused3case-controlstudiesofwhitesubjectswhoseseverityofCADwasassessedbyangiography.Thefirst2studieswereusedtogeneratehypothesesthatwerethentestedinthe...
参考资料医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第9期